The New Science of Preventing Heart Attacks

29.01.2026 • 00:32:54

In recent decades, medical research has fundamentally changed how we think about heart disease. This fresh understanding has opened up new ways to pre...

From Solar Pumps to Everything: Building a Market from Scratch

22.01.2026 • 00:40:58

Samir Ibrahim is the co-founder and CEO of SunCulture. When he started the company, he thought he was solving a simple problem: How do you sell solar-...

Mass-Producing Stem Cells to Cure Disease

15.01.2026 • 00:34:22

Nabiha Saklayen is the co-founder and CEO of Cellino. Nabiha’s problem is this: How can you make personalized stem cell therapies quickly and cheaply?...

Building a Self-Driving Tractor to Change the Future of Food

18.12.2025 • 00:43:21

Please take our survey https://tinyurl.com/wyplistenersurvey about the show! Tell us what you want to hear, and what would make it better. Tim Buche...

We’re Going to Need a Better Boat

11.12.2025 • 00:35:53

Mitch Lee is the co-founder and CEO of Arc Boats. Mitch's problem is this: How do you build competitively priced electric boats? On today’s show, Mit...

The App Where Strangers Lend Each Other Money

20.11.2025 • 00:45:14

Nina Mohanty is the founder and CEO of Bloom Money. Nina’s problem is this: How do you build an app to help immigrants manage their money? On today’...

Introducing Business History: The Edison Invention People Don't Talk About

18.11.2025 • 00:49:42

What's Your Problem? host Jacob Goldstein has a new show: Business History. How did Hitler’s favorite car become synonymous with hippies? What got T...

Using Sound Waves to Destroy Tumors

13.11.2025 • 00:34:07

Mike Blue is the CEO of HistoSonics. The company recently developed a device that uses ultrasound to destroy tumors. On today’s show, Mike talks abou...

From Desert Robots to Driverless Trucks

06.11.2025 • 00:44:00

Chris Urmson is the co-founder and CEO of Aurora, a company trying to bring autonomous driving to commercial trucking. Chris led a team at the 2004 D...

Is the Future of Fresh Water Under the Sea?

30.10.2025 • 00:31:55

Michael Porter is the Chief Technology Officer of OceanWell. Michael's problem is this: How can you desalinate water at the bottom of the ocean – and...