#555: Marimo Pair - A Canvas for Agent + Developers Collaboration
Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on disk. But t...
#554: Trustworthy AI in Healthcare and Longevity
You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what if the ques...
#553: All of our tools
This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken has moved on...
#552: Astral joins OpenAI
OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's th...
#551: Stroll Down Startup Lane - 2026
If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on...
#550: AI Contributions and Maintainer Load in Open Source
You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added. No issue ...
#549: Great Docs
Your documentation has two audiences now - humans reading the rendered HTML, and AI agents trying to make sense of your library. Rich Iannone and Mich...
#548: Event Sourcing Design Pattern
What if your database worked more like Git? Every change captured as an immutable event you can replay, instead of a single mutating row that quietly ...
#547: Parallel Python at Anyscale with Ray
When OpenAI trained GPT-3, they didn't roll their own orchestration layer. They used Ray, an open source Python framework born out of the same Berkele...
#546: Self hosting apps for Python people
The cloud is convenient until it isn't. You upload your photos, sync your contacts, click through the cookie banners. Then prices go up again or you r...