#533: Web Frameworks in Prod by Their Creators

05.01.2026 • 01:01:58

Today on Talk Python, the creators behind FastAPI, Flask, Django, Quart, and Litestar get practical about running apps based on their framework in pro...

#532: 2025 Python Year in Review

29.12.2025 • 01:18:32

Python in 2025 is in a delightfully refreshing place: the GIL's days are numbered, packaging is getting sharper tools, and the type checkers are multi...

#531: Talk Python in Production

18.12.2025 • 01:21:13

Have you ever thought about getting your small product into production, but are worried about the cost of the big cloud providers? Or maybe you think ...

#530: anywidget: Jupyter Widgets made easy

13.12.2025 • 01:11:21

For years, building interactive widgets in Python notebooks meant wrestling with toolchains, platform quirks, and a mountain of JavaScript machinery. ...

#529: Computer Science from Scratch

03.12.2025 • 01:17:00

A lot of people building software today never took the traditional CS path. They arrived through curiosity, a job that needed automating, or a late-ni...

#528: Python apps with LLM building blocks

30.11.2025 • 01:16:46

In this episode, I’m talking with Vincent Warmerdam about treating LLMs as just another API in your Python app, with clear boundaries, small focused e...

#527: MCP Servers for Python Devs

10.11.2025 • 01:06:25

Today we’re digging into the Model Context Protocol, or MCP. Think LSP for AI: build a small Python service once and your tools and data show up acros...

#526: Building Data Science with Foundation LLM Models

01.11.2025 • 01:07:24

Today, we’re talking about building real AI products with foundation models. Not toy demos, not vibes. We’ll get into the boring dashboards that save ...

#525: NiceGUI Goes 3.0

27.10.2025 • 01:17:46

Building a UI in Python usually means choosing between "quick and limited" or "powerful and painful." What if you could write modern, component-based ...

#524: 38 things Python developers should learn in 2025

20.10.2025 • 01:09:15

Python in 2025 is different. Threads really are about to run in parallel, installs finish before your coffee cools, and containers are the default. In...